The purpose of this research was to formulate tasteless complex of famotidine with Indion 214 (exchangeable ion is H+) and to evaluate molecular properties of drug complexes. The effect of batch process, complexation time, pH and drug- resin ratio on famotidine loading on Indion is reported. Drug-resin complexe (DRC) was characterized by infrared spectroscopy. The efficient drug loading was evident in batch process using Indion 214 with drug-resin ratio of 1:1.5 in 180 minutes. It was observed that optimum drug loading was achieved at 7.5 pH and was not much increased at pH higher than it. IR spectroscopy revealed complexation of –NH (drug) with Indion 214. In-vitro taste studies of DRC shown that drug release from DRC in salivary pH was insufficient to impart bitter taste. Effective and satisfactory taste masking can be obtained by using Indion 214 as ion-exchange resin this complex can be use for oral formulations.
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